High-Intensity Exercise and Hippocampal Integrity in Adults With Cannabis Use Disorder

Does 12 weeks of high-intensity interval training lead to greater improvements in hippocampal health among individuals with cannabis use disorder compared with 12 weeks of strength and resistance training?This randomized clinical trial showed that neither high-intensity interval training nor strength and resistance training led to any detectable increases in hippocampal health.High-intensity interval training does not appear to improve hippocampal health or related cognitive functioning and mental health symptoms while cannabis use persists; however, the findings suggest that with appropriate supports, individuals with cannabis use disorder can successfully participate in intensive exercise programs.

Corresponding Author: Murat Yücel, PhD, QIMR Berghofer, 300 Herston Rd, Herston, Brisbane, QLD 4006, Australia (murat.yucel@qimrb.edu.au).

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