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Thyroid Lobectomy vs Total Thyroidectomy in Indeterminate Molecular Risk Thyroid Cancer: A Randomized Clinical Trial

JAMA Otolaryngology–Head & Neck Surgery 10.1001/jamaoto.2026.2258

August 20, 2026 at 11:00 AM EDT

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This randomized clinical trial sought to determine the proportion of eligible patients who would consent to randomization and complete either thyroid lobectomy or total thyroidectomy as assigned, with the goal of informing target enrollment of a future multicenter trial.

Corresponding Author: Masha J. Livhits, MD, Section of Endocrine Surgery, Department of Surgery, UCLA David Geffen School of Medicine, University of California, Los Angeles, 10833 LeConte Ave, CHS 72-215, Los Angeles, CA 90095 (MLivhits@mednet.ucla.edu).

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