Clinical Challenge

An Unusual Tongue MassAn Unusual Tongue Mass—CaseAn Unusual Tongue Mass—Diagnosis

JAMA Otolaryngology–Head & Neck Surgery 10.1001/jamaoto.2026.1394

June 11, 2026 at 11:00 AM EDT

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A 63-year-old man presented with an indurated submucosal lesion with overlying taut, blanched mucosa and surrounding erythema on the posterior ventral aspect of the right side of the tongue. Histopathologic examination revealed noncaseating granulomatous inflammation without evidence of dysplasia. What is your diagnosis?

Corresponding Author: Christopher M. K. L. Yao, MD, Princess Margaret Cancer Centre, Department of Otolaryngology–Head christophermkl.yao@uhn.ca).

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