Review

Radiomics in Otolaryngology–Head and Neck Surgery

JAMA Otolaryngology–Head & Neck Surgery 10.1001/jamaoto.2025.5462

February 12, 2026 at 11:00 AM EST

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The results of this Review suggest that radiomics is a promising tool that can be integrated with clinical and pathologic data to enhance diagnosis, optimize prognostication, and personalize treatment in otolaryngology. Standardization of imaging protocols, rigorous validation in multi-institutional cohorts, and integration with clinical workflows remain critical prerequisites for clinical application. With continued refinement and integration, radiomics applications may help streamline clinical workflows and guide treatment planning.

Corresponding Author: Alexandra T. Bourdillon, MD, Department of Otolaryngology–Head alexandra.bourdillon@ucsf.edu).

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