Clinical Trial Termination or Withdrawal in Head and Neck Squamous Cell Carcinoma

What characteristics of head and neck squamous cell carcinoma (HNSCC) clinical trials are associated with failure, defined as termination or withdrawal?In this case-control study of 346 failed trials and 346 completed control trials, industry-sponsored, phase 1 trials, and trials investigating immunotherapy and targeted therapy were more likely to fail due to strategic decisions, while non–industry-sponsored trials, later-phase trials, and trials investigating other treatment types more commonly cited failure due to poor recruitment.Strategic assessment of HNSCC clinic trial characteristics associated with failure may help overcome commonly cited reasons for failure.

Corresponding Author: Alex S. Reznik, BS, Medical Scientist Training Program, University of Miami Miller School of Medicine, 1600 NW 10th Ave, Miami, FL 33136 (asr2224@med.miami.edu).

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