Ultra-Widefield Fluorescein Angiographic Quantitative Leakage Parameters and Clinical Outcomes in Nonproliferative Diabetic Retinopathy

Is retinal leakage on ultra-widefield fluorescein angiography associated with progression of diabetic retinopathy (DR)?In cohort study involving a post hoc analysis of 537 eyes with nonproliferative DR, higher baseline leakage index and a 1% or greater increase at 1 year were associated with greater risk of DR worsening, vitreous hemorrhage, and proliferative DR over 4 years.Quantitative leakage measurements may serve as promising biomarkers to predict DR progression and complications, supporting their potential use in clinical practice and trials for risk stratification and monitoring.

Corresponding Author: Kristin Josic, PhD, Jaeb Center for Health Research, 15310 Amberly Dr, Ste 350, Tampa, FL 33647 (drcrstat2@jaeb.org).

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