Original Investigation

Disparities in Cancer Incidence by Sex and Associated Lifestyle Factors and Health Conditions

JAMA Oncology 10.1001/jamaoncol.2026.3747

September 24, 2026 at 11:00 AM EDT

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The findings of this cohort study suggest that modifiable lifestyle factors and health conditions accounted for most of the male-female cancer incidence gap in the Chinese population but only a small fraction in the UK population. Reducing cancer sex disparities may require prevention strategies tailored to population contexts.

Corresponding Author: Yong-Bing Xiang, MD, MSc, State Key Laboratory of Systems Medicine for Cancer, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine, No. 25, Ln 2200, Xie Tu Rd, Shanghai 200032, PR China (ybxiang@shsci.org).

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