Proton Craniospinal Irradiation for Patients With Leptomeningeal Metastasis

Does proton craniospinal irradiation (pCSI) result in improved survival outcomes compared with involved-field radiotherapy (IFRT) in patients with solid tumor leptomeningeal metastases (LMs)?In this randomized clinical trial of 98 patients with solid tumor LM that evaluated radiotherapy approaches, there were superior survival outcomes with pCSI compared with IFRT for patients with non–small cell lung cancer or breast cancer LM.The findings of this trial suggest that pCSI should be considered as a treatment of option of LM if available.

Corresponding Author: Jonathan T. Yang, MD, PhD, Department of Radiation Oncology, NYU Grossman School of Medicine, 160 E 34th St, New York, NY 10016 (jonathan.yang@nyulangone.org).

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