Survival After Fertility-Preserving Hormonal Therapy vs Hysterectomy for Early-Stage Endometrial Cancer

What is the long-term survival of premenopausal women undergoing fertility-preserving hormonal therapy for clinical stage I endometrial cancer?In this cohort study of 15 849 women, there was no difference in survival between hysterectomy and hormonal therapy in patients younger than 40 years. However, for patients aged 40 to 49 years, fertility-preserving hormonal therapy was associated with a significantly increased risk of death.These findings suggest that, while overall survival in patients treated with hormonal therapy is shorter than with hysterectomy, survival for patients younger than 40 years is comparable between fertility-preserving hormonal therapy and hysterectomy.

Corresponding Author: Jason D. Wright, MD, Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Columbia University College of Physicians and Surgeons, 161 Fort Washington Ave, 4th Floor, New York, NY 10032 (jw2459@columbia.edu).

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