Viewpoint

Left Atrial Appendage Occlusion—Is the Case Now Closed?

JAMA Neurology 10.1001/jamaneurol.2026.3292

September 28, 2026 at 11:00 AM EDT

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This Viewpoint disucsses how the results of CLOSURE-AF and CHAMPION-AF should inform decision-making regarding treatment with direct oral anticoagulants vs left atrial appendage closure for left atrial appendage occlusion.

Corresponding Author: David Seiffge, MD, Department of Neurology, Inselspital University Hospital Bern, Rosenbuehlgasse 25, CH-3010 Bern, Switzerland (david.seiffge@insel.ch).

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