Serum Klotho Levels, Brain Structure, and Cognitive Performance

Is circulating klotho a modifier of the adverse association between age-related brain atrophy and cognitive decline in a cognitively unimpaired, older adult cohort enriched for Alzheimer disease (AD) risk?In this cross-sectional study of 308 late middle-aged and older adults enriched for AD risk, higher serum klotho levels mitigated the negative association between age-related brain atrophy (ventricle-brain volume ratio [VBR]) and cognitive performance.Results suggest that protection offered by klotho may be age dependent, supporting further investigation into klotho-based interventions to preserve cognitive function with aging and against AD risk.

Corresponding Author: Ira Frahmand Driscoll, PhD (idriscoll@medicine.wisc.edu), and Ozioma Okonkwo, PhD (ozioma@medicine.wisc.edu), University of Wisconsin - Madison, J5/M192 Clinical Science Center, 600 Highland Ave, Madison, WI 53792.

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