Anti–PD-1 Therapy and Long-Term Toxic Effects Among Patients With Melanoma

In this cohort study of patients with melanoma treated with adjuvant anti–PD-1 therapy, chronic irAEs were common, persistent, and associated with elevated circulating cytokines, suggesting possible candidate inflammatory pathways for future validation. Later irAE onset and corticosteroid-treated irAEs were associated with chronicity of irAEs. Given the long-term survival of these patients, monitoring and managing chronic irAEs is crucial.

Corresponding Author: Douglas B. Johnson, MD, Department of Medicine, Vanderbilt University Medical Center, 1161 21st Aven S, Nashville, TN 37232 (douglas.b.johnson@vumc.org).

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