Research Letter

Adverse Health Outcomes of Psilocybin, LSD, MDMA, Ibogaine, and 5-MeO-DMT

JAMA Network Open 10.1001/jamanetworkopen.2026.36756

September 29, 2026 at 11:00 AM EDT

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This cross-sectional study describes health outcomes attributed to recent use of psilocybin, lysergic acid diethylamide (LSD), 3,4-methylenedioxymethamphetamine (MDMA), ibogaine, and 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) in a nationally representative survey of US adults.

Corresponding Author: Otto Simonsson, PhD, Department of Neurobiology, Care Sciences and Society, Karolinska Institute, Tomtebodavägen 18A, 171 65 Solna, Sweden (otto.simonsson@ki.se).

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