Original Investigation

Inhaled Corticosteroids Continuation in the First Trimester and Pregnancy Outcomes in Women With Asthma

JAMA Network Open 10.1001/jamanetworkopen.2026.30781

August 24, 2026 at 11:00 AM EDT

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This nationwide cohort study found that continued ICS use during early pregnancy was not associated with increased risks of maternal or neonatal outcomes, despite frequent discontinuation. These findings provide reassuring evidence supporting current guideline recommendations to continue ICS therapy during pregnancy and highlight the importance of individualized risk assessment while maintaining asthma control.

Corresponding Authors: Ju-Young Shin, PhD, School of Pharmacy, Sungkyunkwan University, 2066, Seobu-ro, Jangan-gu, Suwon, Gyeonggi-do 16419, South Korea (shin.jy@skku.edu); Yunha Noh, PharmD, PhD, Department of Pharmacy, College of Pharmacy, Chonnam National University, 77, Yongbong-ro, Buk-gu, Gwangju, South Korea (noh.yh@jnu.ac.kr).

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