Original Investigation

In Vitro Fertilization and VACTERL Birth Defects

JAMA Network Open 10.1001/jamanetworkopen.2026.29355

August 19, 2026 at 11:00 AM EDT

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This population-based prospective cohort study identified an association of IVF with the multiple congenital anomaly pattern VACTERL. Although the absolute risk among live births remains low, these findings highlight the need for further investigations of child health outcomes by method of conception.

Corresponding Author: Barbara Luke, ScD, MPH, Department of Obstetrics, Gynecology and Reproductive Biology, College of Human Medicine, Michigan State University, 965 Wilson Rd, 6th Floor, Fee Hall, East Lansing, MI 48824 (lukeb@msu.edu).

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