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Smoking Behavior and Major Cardiovascular and Limb Events in Patients With Peripheral Artery Disease

JAMA Network Open 10.1001/jamanetworkopen.2026.29337

August 19, 2026 at 11:00 AM EDT

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In this cohort study of 189 545 active smokers with newly diagnosed PAD, complete smoking cessation was associated with lower risks of both cardiovascular and limb-specific adverse events, whereas partial smoking reduction showed no significant benefit. These findings support complete cessation as the primary therapeutic target in patients with PAD.

Corresponding Author: Ahram Han, MD, Department of Surgery, Seoul National University Hospital, 101, Daehak-ro, Jongno-gu, Seoul, Republic of Korea (ahramh@gmail.com).

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