Artificially Sweetened and Sugar-Sweetened Beverage Intake and Risk of Liver Cancer

Are artificially sweetened beverage (ASB) and sugar-sweetened beverage (SSB) intakes associated with risk of liver cancer overall and by subtype (hepatocellular carcinoma [HCC] and intrahepatic cholangiocarcinoma [ICC])?In this pooled analysis of 11 prospective cohort studies comprising 1 518 411 adults, SSB intake per 1-beverage/day increment was associated with increased risk of HCC and ICC, whereas ASB intake was not associated with liver cancer overall or by subtype.This study found that SSB consumption was associated with increased risk of liver cancer subtypes, while the evidence did not support an independent association between ASB intake and liver cancer risk.

Corresponding Author: Katherine A. McGlynn, PhD, Division of Cancer Epidemiology and Genetics, National Cancer Institute 9609 Medical Center Dr, Room 6E-446, Rockville, MD 20850 (mcglynnk@nih.gov).

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