Original Investigation

Obstructive Sleep Apnea Risk and Mental Health Conditions Among Older Canadian Adults in the Canadian Longitudinal Study on Aging

JAMA Network Open 10.1001/jamanetworkopen.2025.49137

December 26, 2025 at 11:00 AM EST

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Is high risk of obstructive sleep apnea (OSA) associated with increased odds of concurrent and future mental health conditions among middle-aged and older adults?In this national cohort study of 30 097 individuals, those at high risk of OSA had approximately 40% higher odds of mental health conditions at both baseline and follow-up. Over time, high risk of OSA remained associated with a 44% increased odds of reporting new mental health conditions.These findings bridge knowledge gaps on the association between OSA and mental health during aging, highlighting the need for integrated screening and intervention strategies.

Corresponding Author: Tetyana Kendzerska, MD, PhD, Inflammation and Chronic Disease Program, Ottawa Hospital Research Institute, 1053 Carling Ave, Ottawa, ON K1Y 4E9, Canada (tkendzerska@toh.ca).

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