Abnormal Amyloid-β Duration, Tau, and Neurodegeneration in Cranial Images

Is regional neurodegeneration associated with the timeline of amyloid-β (Aβ) accumulation?In this cohort study that included 370 predominantly cognitively unimpaired individuals with Aβ and tau positron emission tomography alongside longitudinal magnetic resonance imaging data, subtle, accelerated brain region atrophy was observed with Aβ-positivity and Aβ-positivity duration, controlling for individuals who later became tau-positive.These findings suggest that neurodegeneration may begin soon after the onset of abnormal Aβ pathology.

Corresponding Author: Tobey J. Betthauser, PhD, School of Medicine and Public Health, University of Wisconsin–Madison, 610 Walnut St, Suite 448, Madison, WI 53726 (tjbetthauser@medicine.wisc.edu).

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