Research Letter

Potential Impact of Next-Generation Weight Loss Drugs on Cancer Incidence

JAMA Network Open 10.1001/jamanetworkopen.2025.30904

September 08, 2025 at 11:00 AM EDT

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This decision analytical model projects changes in obesity-related cancer incidence among US adults following the potential impact of glucagon-like peptide 1 receptor agonists on weight loss.

Corresponding Author: Darren R. Brenner, PhD, Department of Oncology, Alberta Health Services, 3330 Hospital Dr NW, Calgary, AB T2N 4N1, Canada (darren.brenner@ucalgary.ca).

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