Functional Connectivity Predicting Transdiagnostic Treatment Outcomes in Internalizing Psychopathologies

Can treatment outcomes for patients with internalizing psychopathologies be predicted using whole-brain functional connectivity patterns across different diagnoses and therapeutic modalities?In this prognostic study of predictive models including 181 patients with internalizing psychopathologies randomized to receive 12 weeks of cognitive behavioral therapy, selective serotonin reuptake inhibitor therapy, or support therapy, whole-brain functional connectivity significantly predicted multidimensional symptom changes across individuals, diagnostic categories, and treatment modalities.These findings suggest that functional connectivity patterns may serve as transdiagnostic neural markers of treatment responses across treatment modalities, highlighting the potential of connectome-based predictive models to guide personalized treatment strategies in psychiatry.

Corresponding Author: Zhenfu Wen, PhD, The University of Texas Health Science Center at Houston, 1941 East Rd, Houston, TX 77054 (zhenfu.wen@uth.tmc.edu).

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