Long-Term Survival Among Children With Trisomy 13 and Trisomy 18 by Cytogenetic Status

What are the differences in survival to 10 years of age between children with full trisomy 13 or 18 vs those with mosaic or partial trisomy?In this cohort study of 798 infants with trisomy 13 and 18, survival to 10 years of age was statistically significantly higher among those with mosaic or partial trisomy compared with full trisomy.These findings suggest that survival to 10 years of age may be relatively common among those with mosaicism or partial trisomy, and families of affected children may benefit from tailored prognostic counseling and care.

Corresponding Author: A. J. Agopian, PhD, Department of Epidemiology, University of Texas Health Science Center at Houston School of Public Health, 1200 Pressler St, Houston, TX 77030-3900 (a.j.agopian@uth.tmc.edu).

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