Original Investigation

Resignation in Working Women With Breast and Gynecologic Cancers

JAMA Network Open 10.1001/jamanetworkopen.2025.28844

August 25, 2025 at 11:00 AM EDT

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Is a diagnosis of breast or gynecologic cancer associated with job resignation among working women, and what factors are associated with higher risk?This cohort study of 99 964 working women in Japan younger than 58 years with a diagnosis of breast (59 452 women), cervical (14 713 women), uterine (16 933 women), and ovarian (8866 women) cancer and 999 640 matched controls found that a cancer diagnosis was associated with a higher risk of resignation, particularly among individuals with lower income, older age, and depression history.These findings suggest that targeted workplace support may be necessary to help retain women with cancer in the workforce.

Corresponding Author: Kyoko Nomura, MD, MPH, PhD, Department of Environmental Health Science and Public Health, Akita University Graduate School of Medicine, Akita, Japan (knomura@med.akita-u.ac.jp).

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