Original Investigation

Vascular Function and Cardiorespiratory Fitness in Adults Who Use Nicotine Vapes

JAMA Cardiology 10.1001/jamacardio.2026.4626

October 21, 2026 at 11:00 AM EDT

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Regular daily nicotine vape use in young adults who have never smoked combustible tobacco was associated with lower vascular function and cardiorespiratory fitness. These findings highlight the need for longitudinal studies to determine long-term clinical implications.

Corresponding Author: Maxime Boidin, PhD, School of Sport and Exercise Sciences, Institute of Sport, Manchester Metropolitan University, 99 Oxford Rd, Manchester M1 7EL, United Kingdom (m.boidin@mmu.ac.uk).

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