Intensive vs Standard Blood Pressure Lowering in People With and Without Chronic Kidney Disease

Results of this systematic review and meta-analysis indicate that in adults with or without CKD, intensive BP lowering reduced the risk of cardiovascular events by 15% per 10-mm Hg lower SBP and increased the risk of sustained declines in eGFR, without an increase in risk of kidney failure. However, since baseline cardiovascular risk is higher in CKD, the absolute reduction in cardiovascular events was at least as large in this population; therefore, intensive BP lowering should be recommended in people with and without CKD.

Correspondence Author: Parminder K. Judge, PhD, University of Oxford, Richard Doll Building, Old Road Campus, Headington, Oxford OX3 7LF, UK (parminder.judge@ndph.ox.ac.uk).

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