Long-Term Outcomes of Left Bundle-Branch Pacing vs Biventricular Pacing in Heart Failure

Whether left bundle-branch pacing (LBBP) yields superior clinical outcomes compared with biventricular pacing (BiVP) in patients with heart failure (HF) with left bundle-branch block (LBBB) and severely reduced left ventricular ejection fraction (LVEF)?In this randomized clinical trial, LBBP was associated with a significantly lower risk of all-cause mortality and HF hospitalization when compared with BiVP.These results demonstrated that LBBP was superior to BiVP in reducing the risk of death or HF hospitalization in patients with LBBB and severely reduced LVEF and might be an alternative to BiVP in this patient population.

Corresponding Authors: Yangang Su, MD, PHD (yangangsu@yeah.net), and Junbo Ge, MD, PHD (ge.junbo@zs-hospital.sh.cn), Department of Cardiology, Zhongshan Hospital of Fudan University, Shanghai Institute of Cardiovascular Diseases, National Clinical Research Center for Interventional Medicine, 180 Fenglin Rd, Xuhui District, Shanghai 200032, China.

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