Original Investigation

Semaglutide and Hospitalizations in Patients With Obesity and Established Cardiovascular Disease

JAMA Cardiology 10.1001/jamacardio.2025.4824

December 23, 2025 at 11:00 AM EST

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Does treatment with semaglutide reduce the number of total hospital admissions and duration of hospital stay in patients at high cardiovascular risk with overweight or obesity?This prespecified exploratory analysis of the SELECT randomized clinical trial observed that treatment of patients with semaglutide was associated with a lower rate of first hospital admission for any indication, total hospitalizations, and number of days hospitalized.This finding extends the benefits of treatment with semaglutide beyond cardiovascular prevention to reducing the burden of total hospital admissions.

Corresponding Author: Stephen J. Nicholls, MD, Monash Victorian Heart Institute and Monash University, 631 Blackburn Rd, Melbourne, VIC 3168, Australia (stephen.nicholls@monash.edu).

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