Prevalence and Clinical Implications of Sleep Apnea in Hypertrophic Cardiomyopathy

What is the prevalence of sleep disordered breathing (SDB) in patients with hypertrophic cardiomyopathy (HCM) and its association with myocardial remodeling, subclinical injury, and functional impairment?In this cohort study, 154 patients with hypertrophic cardiomyopathy underwent criterion-standard polysomnography. Previously undiagnosed SDB was identified in 59% of patients and was associated with significantly increased left ventricular mass, diastolic dysfunction, and elevated troponin-T levels.The findings suggest that SDB is a highly prevalent yet underdiagnosed comorbidity in HCM, underscoring the rationale for randomized clinical trials to treat SDB in patients with HCM.

Corresponding Author: Virend K. Somers, MBChB, DPhil, Mayo Clinic, 200 First St NW, Rochester, MN 55905 (somers.virend@mayo.edu).

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