Sodium Bicarbonate for In-Hospital Cardiac Arrest

Does sodium bicarbonate administered during in-hospital cardiac arrest improve return of spontaneous circulation?In this randomized clinical trial that included 779 patients with in-hospital cardiac arrest in Denmark, the proportion of patients who achieved return of spontaneous circulation was 39% in the sodium bicarbonate group and 37% in the placebo group, a difference that was not statistically significant.These findings do not support routine administration of sodium bicarbonate for patients with in-hospital cardiac arrest.

Corresponding Author: Lars Wiuff Andersen, MD, MPH, PhD, DMSc, Department of Anaesthesiology and Intensive Care Medicine, Aarhus University Hospital, Palle Juul-Jensens Blvd 99, 8200 Aarhus N, Denmark (lwandersen@clin.au.dk).

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