Age-Adjusted D-Dimer Cutoff Levels to Rule Out Deep Vein Thrombosis

Does an age-adjusted D-dimer cutoff safely increase the proportion of patients in whom deep vein thrombosis (DVT) can be excluded?In this multinational prospective outcome study including 3205 outpatients presenting to the emergency department with suspected DVT, the age-adjusted D-dimer cutoff safely excluded DVT. Among patients with D-dimer level between 500 µg/L and their age-adjusted cutoff, none developed venous thromboembolism at 3 months. Use of the age-adjusted cutoff resulted in a 7.4% absolute increase in the proportion of patients in whom the diagnosis could be excluded.An age-adjusted D-dimer cutoff may safely rule out DVT and increase diagnostic efficiency, reducing the need for unnecessary imaging.

Corresponding Author: Marc Righini, MD, Division of Angiology and Hemostasis, Department of Medical Specialties, Geneva University Hospital and Faculty of Medicine, 4, rue Gabrielle-Perret-Gentil, CH-1211 Geneva 14, Switzerland (Marc.Righini@hcuge.ch).

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