Fractional Flow Reserve–Guided Complete vs Culprit-Only Revascularization in Non–ST-Elevation Myocardial Infarction and Multivessel Disease

Is fractional flow reserve–guided complete revascularization superior to culprit-only revascularization during the index procedure in patients with non–ST-segment elevation myocardial infarction and multivessel disease?In this randomized clinical trial of 478 patients, a significant reduction of the composite outcome all-cause death, nonfatal myocardial infarction, any revascularization, and stroke at 1 year in the complete revascularization group was found compared with culprit-only revascularization (13 [5.5%] vs 32 [13.6%]).These findings support using fractional flow reserve–guided complete revascularization during the index procedure in patients with non–ST-segment elevation myocardial infarction and multivessel disease.

Corresponding Author: Tobias F. S. Pustjens, MD, Zuyderland Medical Centre, PO Box 5500, NL-6130 MB, Sittard-Geleen, the Netherlands (t.pustjens@gmail.com).

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