Screening After Acute Myocardial Infarction

Does routine screening with urea breath test of patients with myocardial infarction reduce upper gastrointestinal bleeding events?In this nationwide, cluster randomized, crossover clinical trial involving 18 466 patients with myocardial infarction from 35 Swedish hospitals, routine screening did not significantly reduce the risk of upper gastrointestinal bleeding (incidence rate, 16.8 vs 19.2 events per 1000-person-years; rate ratio, 0.90), although a benefit among patients at higher risk of bleeding may exist.Routine screening with urea breath test in patients with myocardial infarction cannot be recommended.

Corresponding Author: Robin Hofmann, MD, PhD, Department of Clinical Science and Education, Division of Cardiology, Karolinska Institutet, Södersjukhuset, 11883 Stockholm, Sweden (robin.hofmann@ki.se).

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