Biparametric vs Multiparametric MRI for Prostate Cancer Diagnosis

Is biparametric magnetic resonance imaging (MRI) noninferior to multiparametric MRI in the detection of clinically significant prostate cancer?In this level-1, prospective, multicenter, within-patient, noninferiority trial of 490 biopsy-naive men, biparametric MRI was noninferior to multiparametric MRI for detection of Gleason Grade Group 2 or higher prostate cancer (difference, −0.4 percentage points).In men with suspected prostate cancer, provided that image quality is adequate, an abbreviated biparametric MRI, with or without targeted biopsy, could become the new standard of care for prostate cancer diagnosis.

Corresponding Author: Veeru Kasivisvanathan, PhD, Division of Surgery and Interventional Science, University College London, 3rd Floor, Charles Bell House, 43-45 Foley St, London W1W 7TS, United Kingdom (veeru.kasi@ucl.ac.uk).

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