Opportunities for Pragmatic Design Elements in Surgical Trials

Increasing the use of PCTs presents an opportunity to overcome the challenges of surgical RCTs. However, there is a need to prioritize questions that matter most to patients and health care professionals and to develop improved training, funding, and institutional support for PCTs in surgery.

Corresponding Author: Steven Clark Cunningham, MD, MLA, Division of Oncology, Office of Oncologic Drugs, Office of New Drugs, Center for Drug Evaluation and Research, US Food and Drug Administration, 10903 New Hampshire Ave, Silver Spring, MD 20993 (steven.cunningham@fda.hhs.gov).

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