Original Investigation

Collaborative Care for Opioid Use Disorder in Primary Care

JAMA Psychiatry 10.1001/jamapsychiatry.2025.2126

August 20, 2025 at 11:00 AM EDT

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Is collaborative care for opioid use disorder and co-occurring mental health symptoms superior to collaborative care for co-occurring mental health symptoms alone?In this cluster randomized clinical trial including 254 participants, collaborative care that treats both opioid use disorder and co-occurring mental health symptoms is more effective at reducing the number of days of nonmedical use of opioids (but not mental health–related quality of life) than collaborative care that only treats co-occurring mental health symptoms.These findings indicate that opioid use disorder can be effectively managed in primary care and that collaborative care that treats both opioid use disorder and mental health is a better treatment option than collaborative care that only treats mental health.

Corresponding Author: John C. Fortney, PhD, Department of Psychiatry and Behavioral Sciences, Division of Population Health, University of Washington School of Medicine, 1959 NE Pacific St, Box 356560, Seattle, WA 98195-6560 (fortneyj@uw.edu).

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