Original Investigation

Effectiveness of Oseltamivir in Hospitalized Children With Laboratory-Confirmed Influenza, 2014-2023

JAMA Pediatrics 10.1001/jamapediatrics.2026.3376

August 10, 2026 at 11:00 AM EDT

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In this cohort of children hospitalized with influenza, oseltamivir treatment was significantly associated with a reduced risk of ICU admission by 31% and decreased hospital LOS. These findings demonstrate the benefits of oseltamivir receipt and support current national recommendations for oseltamivir treatment as soon as possible in children hospitalized with suspected or laboratory-confirmed influenza.

Corresponding Author: Suchitra Rao, MBBS, MSCS, University of Colorado School of Medicine and Children’s Hospital Colorado, 13123 E 16th Ave, Box 090, Aurora, CO 80045 (suchitra.rao@childrenscolorado.org).

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