Original Investigation

Individualized Prognostic Counseling for Decision-Making in Head and Neck Cancer

JAMA Otolaryngology–Head & Neck Surgery 10.1001/jamaoto.2025.4838

January 02, 2026 at 11:00 AM EST

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Is use of an individualized counseling prognostic model associated with reduced decisional conflict and regret in patients with head and neck squamous cell carcinoma (HNSCC)?In this nonrandomized clinical trial including 458 patients with primary HNSCC, individualized counseling with an online prognostic model was associated with reductions in decisional conflict and regret vs standard counseling.The findings suggest that individualized counseling with an online prognostic model was associated with improved decision-making in patients with HNSCC by reducing uncertainty and fostering more active participation in treatment choices.

Corresponding Author: Maarten C. Dorr, PhD, MD, Department of Otorhinolaryngology and Head and Neck Surgery, Erasmus MC Cancer Institute, Erasmus University Medical Center, Dr. Molewaterplein 40, 3015 GD Rotterdam, the Netherlands (m.dorr@erasmusmc.nl).

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