Original Investigation

Standardized Lacrimal Sac Massage vs Probing for Congenital Nasolacrimal Duct Obstruction in Infants

JAMA Ophthalmology 10.1001/jamaophthalmol.2026.3169

August 13, 2026 at 11:00 AM EDT

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For infants younger than 1 year with CNLDO, lacrimal sac massage for 3 months was noninferior to lacrimal duct probing in efficacy, with no serious complications in either group. These findings support lacrimal sac massage as an alternative to surgical probing for CNLDO in infants younger than 1 year similar to those enrolled in this trial.

Corresponding Authors: Xuanwei Liang, PhD (liangxuanwei@163.com), and Zuohong Li, PhD (lpplizuohong@163.com), State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, 54 S Xianlie Rd, Guangzhou 510060, China.

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