Original Investigation

Ten Years of Ocrelizumab in Relapsing Multiple Sclerosis

JAMA Neurology 10.1001/jamaneurol.2026.3507

October 05, 2026 at 11:00 AM EDT

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In the OPERA I and II randomized clinical trials, continuous OCR treatment over 10 years provided greater benefit in preserving function than a 2-year delay in initiating OCR, reinforcing the importance of early high-efficacy treatment.

Corresponding Author: Stephen L. Hauser, MD, UCSF Weill Institute for Neurosciences, University of California, San Francisco, 1651 4th St, San Francisco, CA, 94158 (stephen.hauser@ucsf.edu).

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