Review

MRI Characteristics of Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease

JAMA Neurology 10.1001/jamaneurol.2026.3196

September 28, 2026 at 11:00 AM EDT

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MRI is central to MOGAD evaluation, and recognition of the characteristic imaging features and lesion dynamics outlined in this review can aid diagnosis. Application of the standardized MRI protocol summarized here can optimize use in clinical practice and promote harmonization across research studies. Future imaging and artificial intelligence applications may improve diagnosis, disease monitoring, and understanding of MOGAD pathogenesis.

Corresponding Authors: Eoin P. Flanagan, MD, Department of Neurology and Center for Multiple Sclerosis and Autoimmune Neurology, Mayo Clinic, 200 First St SW, Rochester, MN 55905 (flanagan.eoin@mayo.edu); Jacqueline Palace, MD, University of Oxford, Headley Way, Oxford OX3 9DU, United Kingdom (jacqueline.palace@ndcn.ox.ac.uk).

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