Neurological Manifestations in Adult Survivors of Ebola Virus Disease

What neurological symptoms are present in adult survivors of Ebola virus disease (EVD) and how long are they present after infection?In this cohort study conducted in Liberia including 148 EVD survivors and 81 control individuals, survivors had a wide range of neurological symptoms during acute EVD (including headaches, altered mental status, and meningitis symptoms) and numerous neurological sequelae in convalescence (including headaches, memory loss, and neurological examination abnormalities). Seven years later, most survivors’ symptoms and findings had improved, but many still had neurological symptoms, most notably memory loss.The findings indicate that many neurological symptoms, including those that can affect quality of life and socioeconomic burden, were associated with EVD, warranting close neurological follow-up of EVD survivors.

Corresponding Author: Bridgette Jeanne Billioux, MD, National Institute of Neurological Disorders and Stroke, National Institutes of Health, 10 Center Dr, Bldg 10, Room 2A23J, Bethesda, MD 20892 (Bridgette.billioux@nih.gov).

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