Long-Term Exposure to Air Pollution and Risk and Prognosis of Motor Neuron Disease

Is long-term exposure to air pollution associated with the risk and prognosis of motor neuron disease (MND)?In this nested case-control study including 1463 patients with newly diagnosed MND, 7310 age- and sex-matched population controls, and 1768 sibling controls, long-term exposure to air pollution was associated with an increased risk of MND as well as increased mortality and faster disease progression after MND diagnosis.These findings suggest that long-term exposure to air pollution may contribute to the development of MND and accelerate disease progression.

Corresponding Authors: Jing Wu, PhD, (jing.wu@ki.se), and Fang Fang, MD, PhD, (fang.fang@ki.se), Unit of Integrative Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Nobelsväg 13, Solna 17177, Sweden.

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