Original Investigation

Incidence and Prevalence of Frontotemporal Dementia

JAMA Neurology 10.1001/jamaneurol.2025.3307

September 08, 2025 at 11:00 AM EDT

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What is the incidence and prevalence of frontotemporal dementia (FTD)?In this systematic review and meta-analysis of population-based studies with an analyzed population of approximately 31 million person-years for incidence and 6 million individuals for prevalence spread in more than 12 regions around the world, FTD pooled incidence was 2.28 (95% CI, 1.55-3.36) per 100 000 person-years, and pooled prevalence was 9.17 (95% CI, 3.59-23.42) per 100 000 people.With these results providing a robust pooled estimate of FTD incidence and prevalence, future research should include underrepresented populations and other world regions to better comprehend the global burden of FTD.

Corresponding Authors: Daniele Urso, MD, MPH, Center for Neurodegenerative Diseases and the Aging Brain, Department of Clinical Research in Neurology, University of Bari ‘Aldo Moro,’ “Pia Fondazione Cardinale G. Panico,” Via S Pio X 4, Tricase 73039, Lecce, Italy (danieleurso010@gmail.com).

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