Original Investigation

Gadolinium-Enhanced Aneurysm Wall Imaging and Risk of Intracranial Aneurysm Growth or Rupture

JAMA Neurology 10.1001/jamaneurol.2025.3209

September 08, 2025 at 11:00 AM EDT

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What is the 4-year risk of instability (growth/rupture) of unruptured intracranial aneurysms (UIAs) with aneurysm wall enhancement (AWE) on magnetic resonance imaging (MRI) at baseline?In this cohort study including 1351 patients, the 4-year risk of instability occurred in one-third of UIAs with circumferential AWE. Circumferential AWE was an independent predictor of instability.Results suggest that MRI aneurysm wall imaging may be used for predicting the risk of aneurysm instability.

Corresponding Authors: Shuo Wang, MD, Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, No.119 South 4th Ring West Road, Fengtai District, Beijing 100071, China (captain9858@126.com); Chengcheng Zhu, PhD, Department of Radiology, University of Washington, 325 9th Ave, Seattle, WA 98104 (zhucheng@uw.edu).

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