Ischemic Stroke Incidence and Severity and Poststroke Cognitive Decline and Incident Dementia

Are stroke incidence and severity associated with long-term cognitive decline and dementia risk?In this cohort study 42 342 participants, higher stroke severity was associated with progressively steeper cognitive decline. Compared with participants without stroke, the risk of dementia was significantly increased in those with stroke, with nearly twice the risk for minor stroke, more than 3 times the risk for mild to moderate stroke, and 5 times the risk for moderate to severe stroke.These findings underscore the importance of identifying mechanisms for the observed associations.

Corresponding Author: Silvia Koton, PhD, MOccH, RN, Optimal Aging Institute, NYU Langone Health, 227 E 30th St, 7th Floor, New York, NY 10016 (silvia.koton@nyulangone.org).

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