Original Investigation

Survival Outcomes Following Preemptive vs Nonpreemptive Kidney Transplantation

JAMA Network Open 10.1001/jamanetworkopen.2026.37964

October 08, 2026 at 11:00 AM EDT

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In this study, preemptive transplantation was not associated with improved patient survival but was associated with lower rates of delayed graft function and death-censored graft failure. Findings challenge presumed survival advantages and suggest preemptive strategies should focus on preventing early graft dysfunction and optimizing use of high-risk kidneys rather than expected mortality benefit.

Corresponding Author: Christie Rampersad, MD, Ajmera Transplant Centre, Toronto General Hospital, University Health Network, SR385-820 Sherbrook St, Winnipeg, MB R3A 1R9, Canada (crampersad@hsc.mb.ca).

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