Hypertensive Disorders of Pregnancy and Incident Dementia

In this cohort study, HDPs were associated with an increased risk of incident dementia after adjustment for baseline maternal, socioeconomic, and obstetric factors. However, this association was no longer statistically significant after additional adjustment for postdelivery vascular and metabolic conditions. Given the small number of dementia events among females with HDPs, these findings should be interpreted cautiously. These findings suggest that HDPs may serve as an early-life marker of long-term neurovascular vulnerability.

Corresponding Authors: Jee Yoon Park, MD, PhD, Department of Obstetrics and Gynecology, Seoul National University Bundang Hospital, Seongnam-si, Gyeonggi-do 13620, Republic of Korea (jyparkmd08@snu.ac.kr); Hyeongsu Kim, MD, PhD, Department of Preventive Medicine, Konkuk University College of Medicine, Chungju-si, Chungcheongbuk-do 27478, Republic of Korea (mubul@kku.ac.kr).

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