Original Investigation

Chatbot Intervention and Cancer Risk Knowledge in Adolescents and Young Adults With Cancer Predisposition

JAMA Network Open 10.1001/jamanetworkopen.2026.35794

October 07, 2026 at 11:00 AM EDT

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In this randomized clinical trial, use of a chatbot-based intervention combined with a cancer predisposition clinic visit improved knowledge of cancer risk by age 30 years over a clinic visit alone, without increasing distress. Combining human interaction in the clinic with personalized, accurate electronic information can support AYAs with cancer predisposition and other serious conditions.

Corresponding Author: Jennifer W. Mack, MD, MPH, Department of Pediatric Oncology, Dana-Farber Cancer Institute, 450 Brookline Ave, Boston, MA 02215 (jennifer_mack@dfci.harvard.edu).

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