Original Investigation

Prophylactic vs Therapeutic Anticoagulation in Hospitalized Patients With COVID-19

JAMA Network Open 10.1001/jamanetworkopen.2026.35333

September 23, 2026 at 11:00 AM EDT

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In patients hospitalized with COVID-19, in-hospital therapeutic anticoagulation with LMWH followed by edoxaban to day 42 did not statistically significantly reduce death and/or thromboembolic events compared with prophylactic anticoagulation followed by placebo.

Corresponding Authors: Mahir Karakas, MD, PhD, MBA, Department of Intensive Care Medicine, University Medical Center Hamburg, Martinistrasse 52, 20251 Hamburg, Germany (m.karakas@uke.de).

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