Original Investigation

Dietary Fat Intake and Mortality Among Patients With Nonmetastatic Prostate Cancer

JAMA Network Open 10.1001/jamanetworkopen.2026.30693

September 02, 2026 at 11:00 AM EDT

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In this cohort study of patients with nonmetastatic prostate cancer, saturated fats, including animal fats, were associated with greater all-cause mortality owing to deaths from cardiovascular disease and other cancers. Diets rich in monounsaturated and polyunsaturated fats and plant-based fats after prostate cancer diagnosis were associated with improved survival outcomes for patients. These findings support evidence-based recommendations for patients and clinicians around dietary fat consumption to improve survivorship outcomes in the clinical setting of nonmetastatic prostate cancer.

Corresponding Author: Lorelei Mucci, ScD, MPH, Department of Epidemiology, Harvard TH Chan School of Public Health, 677 Huntington Ave, Room 902, Boston, MA 02115 (lmucci@hsph.harvard.edu).

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